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The extent and clinical significance of this effect remain subjects of ongoing investigation, and individual responses vary considerably based on genetic factors affecting pigmentation, baseline skin characteristics, concurrent skincare practices and sun exposure, and overall health status affecting skin appearance

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And three of those know when its due indicating that they are right at the edge of their treatment envelope

Pediatr., 109, 984-988, 1986.

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Covered code lists are MAC-specific, so verify with your Medicare Administrative Contractors Local Coverage Determination